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. 2021 Jul 13;9:57. doi: 10.1186/s40364-021-00289-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Gene enrichment analysis of the 9 miRNA-biological signature. Enrichment analysis of 7 T/N-downregulated (a), and 2 T/N-upregulated (b) miRNA gene targets. Analysis was performed by GSEA 4.1.0 software (BROAD Inst.) and run in pre-ranked mode. Predicted targets were ranked based on the correlation coefficients obtained from miRNA\mRNA TCGA RNA-sequencing data. Results showed normalized scores for negative enrichment (a) and positive enrichment (b). Color bar indicates the false discovery rate and the circle size represents the percentage of the genes in the core enrichment pathway. Abbreviations: T/N = tumor versus normal; NES = normalized enrichment score; path. = pathway; sign. = signaling