Table 3.
Q-TWiST analysis for patients who achieved CR or CRi with CPX-351 or 7 + 3
| Mean (SD) duration of health state, days | Means difference (95% CI), days | ||
|---|---|---|---|
| CPX-351 (n = 73) | 7 + 3 (n = 52) | ||
| Health state | |||
| TOX | 81 (44) | 74 (46) | 7 (− 9, 23) |
| TWiST | 747 (744.5) | 521 (659) | 226 (− 29, 481) |
| REL | 65 (131.5) | 28 (55) | 37 (− 2, 75) |
| Q-TWiST | 820 (721) | 572 (650) | 248 (− 1, 496) |
| Relative Q-TWiST gain | 39.8% | ||
Q-TWiST, Quality-adjusted Time Without Symptoms of disease or Toxicity; CR, complete remission; CRi, complete remission with incomplete neutrophil or platelet recovery; SD, standard deviation; CI, confidence interval; TOX, time with any grade 3 or 4 adverse events or before relapse; TWiST, time in remission without relapse or grade 3 or 4 adverse events; REL, time after relapse