| Methods |
Randomised trial with concurrent eligible patients outside of the RCT. Children whose parents or physician refused randomization were treated according to their choice. Children with acute lymphocytic leukemia who had been on continuous chemotherapy for a minimum of three years, regardless of the therapy regimen. No losses to follow up. |
| Data |
Characteristics of non‐RCT patients presented and compared to RCT patients who received the same treatment. RCT maintenance chemotherapy children were 22 boys and 22 girls, age uncertain. Non‐RCT maintenance chemotherapy patients were 16 boys and 8 girls, age uncertain. |
| Comparisons |
Two RCT arms, the experimental arm was compared with similarly treated eligible non‐RCT patients. The experimental arm children were given continuation of maintenance chemotherapy for another three years. Chemotherapy was discontinued in the control group. |
| Outcomes |
Clinical outcomes were assessed in all the children, they were followed up approximately 25 months. Main outcome in this study was relapse. |
| Notes |
The experimental treatment was more beneficial than the control treatment. |
