| Methods |
N of 1 trial with concurrent eligible patients randomized to standard practice. The non‐N of 1 patients were not in the trial because they were randomized to standard practice. Patients with irreversible chronic airflow limitation. N of 1 group lost 2 (14%) patients to follow up, in standard practice 3 (25%) patients were lost to follow up. |
| Data |
N of 1 patients were compared to patients randomized to be treated in standard practice. N of 1 patients were mean 68 (7) years. Standard practice patients were mean 71 (8) years. |
| Comparisons |
Two RCT arms, patients were randomized to N of 1 trial or standard practice. In the N of 1 trial, patients received theophylline for 10 days and placebo for 10 days in a randomized cross over design. For standard practice patients theophylline was stopped and resumed if their dyspnoea worsened. |
| Outcomes |
Clinical outcomes were assessed in all the patients. Patients were followed for 6 months. Main outcome was improvement (6 month distance minus baseline distance) in six minutes walking distance (m). |
| Notes |
The walking distance was not significantly different between N of 1 and standard practice. |
