| Methods |
Randomised trial with concurrent eligible patients outside of the RCT. The non‐RCT patients refused randomization because of preference for one of the tests. Women who requested fetal karyotyping with singleton pregnancy at 10 to 23 weeks gestation. No losses to follow up. |
| Data |
Characteristics of non‐RCT patients presented and compared to RCT patients who received the same treatment. RCT chorionic villus sampling patients were on average 38 (22 to 46) years. Non‐RCT chorionic villus sampling patients were on average 38 (22 to 46) years. |
| Comparisons |
Two RCT arms, both arms were compared with similarly treated eligible non‐RCT patients. The experimental arm patients were tested with the amniocentesis technique. The control patients were tested with chorionic villus sampling. |
| Outcomes |
Clinical outcomes were assessed in all women, they were followed up until delivery. Main outcome in this study was spontaneous fetal death. |
| Notes |
The control treatment was safer (fewer spontaneous deaths) than the experimental treatment. |
