TABLE 2.

Results of Cox Proportional Models Evaluating Associations Between Participant Characteristics and Each Event of Interest

Independent Variables	Crude HR	95% CI	Adjusted HR	95% CI
Outcome: GDRD
Assigned sex at birth
Male (AMAB)	1.0	Reference	1.0	Reference
Female (AFAB)	1.5	1.2–1.9	1.3	1.0–1.7
Race and/or ethnicity
Non-Hispanic white children	1.0	Reference	1.0	Reference
Other groups	0.8	0.6–1.0	0.8	0.6–1.0
Age at index date, y
3–9	1.0	Reference	1.0	Reference
10–14	2.0	1.3–3.0	2.0	1.3–3.0
≥15	2.8	1.9–4.1	2.7	1.8–3.9
Study site
Georgia	1.0	Reference	1.0	Reference
Northern California	1.0	0.8–1.2	1.0	0.8–1.3
Southern California	0.5	0.2–1.3	0.5	0.2–1.3
Outcome: GAHT initiationa
Recorded sex at birth
Male (AMAB)	1.0	Reference	1.0	Reference
Female (AFAB)	3.0	2.2–4.0	2.5	1.8–3.3
Race and ethnicity
Non-Hispanic white children	1.0	Reference	1.0	Reference
Other groupsb	0.6	0.5–0.8	0.6	0.5–0.8

^aModel was stratified on age and study site because of violation of proportional hazards assumption for these 2 variables; for this reason, the results are controlled for age and study site, but no HR estimates are provided.

^bIncludes persons with unknown race and ethnicity.