Table 1:
Baseline characteristics of privately insured patients with atrial fibrillation and CHA2DS2-VASC scores ≥2, by randomization status to early and delayed intervention cohorts
| All members meeting inclusion criteria with CHA2DS2-VASC scores ≥2 | Randomized to delayed intervention | Randomized to early intervention | |||||
|---|---|---|---|---|---|---|---|
| Totals | 241,044 | 120,522 | 120,522 | ||||
| N | % | N | % | N | % | P-value | |
| Age | 0.69 | ||||||
| <30–44 | 646 | 0.3 | 338 | 0.3 | 308 | 0.3 | |
| 45–64 | 19,529 | 8.1 | 9,747 | 8.1 | 9,782 | 8.1 | |
| 65–74 | 74,774 | 31.0 | 37,372 | 31.0 | 37,402 | 31.0 | |
| 75–80+ | 146,095 | 60.6 | 73,065 | 60.6 | 73,030 | 60.6 | |
| Female sex | 112,500 | 47 | 56,085 | 47 | 56,415 | 47 | 0.18 |
| Geographic Region | 0.09 | ||||||
| New England | 9,778 | 4 | 4,931 | 4 | 4,847 | 4 | |
| Mid-Atlantic | 12,543 | 5 | 6,290 | 5 | 6,253 | 5 | |
| South-Atlantic | 130,707 | 54 | 65,064 | 54 | 65,643 | 55 | |
| Midwest | 59,317 | 25 | 29,923 | 25 | 29,394 | 24 | |
| Mountain | 11,702 | 5 | 5,903 | 5 | 5,799 | 5 | |
| Pacific | 16,941 | 7 | 8,385 | 7 | 8,556 | 7 | |
| Unknown | 56 | 0 | 26 | 0 | 30 | 0 | |
| Anemia | 118,343 | 49 | 59,076 | 49 | 59,267 | 49 | 0.44 |
| Hypertension | 229,059 | 95 | 114,470 | 95 | 114,589 | 95 | 0.26 |
| Diabetes | 100,438 | 42 | 49,941 | 41 | 50,497 | 42 | 0.02 |
| Peripheral vascular disease | 72,396 | 30 | 36,172 | 30 | 36,224 | 30 | 0.82 |
| Prior cerebrovascular or thromboembolic event | 75,434 | 31 | 37,835 | 31 | 37,599 | 31 | 0.30 |
| Prior cerebrovascular event | 54,495 | 23 | 27,206 | 23 | 27,289 | 23 | 0.69 |
| Stroke or TIA | 45,262 | 19 | 22,620 | 19 | 22,642 | 19 | 0.91 |
| TIA | 34,948 | 15 | 17,495 | 15 | 17,453 | 15 | 0.81 |
| Stroke | 22,954 | 10 | 11,438 | 10 | 11,516 | 10 | 0.59 |
| Heart failure | 108,588 | 45 | 54,426 | 45 | 54,162 | 45 | 0.28 |
| Kidney disease | 16,913 | 7 | 8,392 | 7 | 8,521 | 7 | 0.30 |
| Dialysis | 7,813 | 3 | 3,917 | 3 | 3,896 | 3 | 0.81 |
| History of MI | 27,070 | 11 | 13,495 | 11 | 13,575 | 11 | 0.61 |
| History of CABG | 34,230 | 14 | 17,062 | 14 | 17,168 | 14 | 0.54 |
| CHA2DS2-VASC | 0.36 | ||||||
| 0–1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 2 | 24,413 | 10 | 12,209 | 10 | 12,204 | 10 | |
| 3 | 44,148 | 18 | 22,133 | 18 | 22,015 | 18 | |
| 4 | 56,459 | 23 | 28,154 | 23 | 28,305 | 24 | |
| 5 | 49,625 | 21 | 24,847 | 21 | 24,778 | 21 | |
| 6 | 33,941 | 14 | 17,121 | 14 | 16,820 | 14 | |
| 7 | 19,385 | 8 | 9,570 | 8 | 9,815 | 8 | |
| 8 | 10,256 | 4 | 5,105 | 4 | 5,151 | 4 | |
| 9 | 2,817 | 1 | 1,383 | 1 | 1,434 | 1 | |
| Mean | 5 | NA | 5 | NA | 5 | NA | >0.99 |
| SD | 1.7 | NA | 1.6 | NA | 1.7 | NA | |
| Atria score | 0.44 | ||||||
| <= 3 (low) | 120,402 | 50 | 60,312 | 50 | 60,090 | 50 | |
| 4 (intermediate) | 33,558 | 14 | 16,677 | 14 | 16,881 | 14 | |
| 5 (high) | 87,084 | 36 | 43,533 | 36 | 43,551 | 36 | |
| Hospitalizations in the prior 6 months | 0.54 | ||||||
| 0 | 206,381 | 86 | 103,208 | 86 | 103,173 | 86 | |
| 1 | 26,934 | 11 | 13,451 | 11 | 13,483 | 11 | |
| 2 | 5,490 | 2 | 2,715 | 2 | 2,775 | 2 | |
| ≥3 | 2,239 | 1 | 1,148 | 1 | 1,091 | 1 | |
*
OAC use at baseline was defined as any OAC use in the prior 12 months.