Table 2:
Patients Not Using an OAC at Baseline* | Patients Using an OAC at Baseline* | P-value | ||||
---|---|---|---|---|---|---|
Totals | 43,826 | 76,696 | ||||
N | % | N | % | |||
Age | <0.0001 | |||||
<30–44 | 150 | 0.3 | 158 | 0.2 | ||
45–64 |
3,375 | 7.7 | 6,407 | 8.4 | ||
65–74 |
13,343 | 30.4 | 24,059 | 31.4 | ||
75–80+ |
26,958 | 61.5 | 46,072 | 60.1 | ||
Female sex | 21,171 | 48 | 35,244 | 46 | <0.0001 | |
Geographic Region | <0.0001 | |||||
New England | 1,245 | 3 | 3,602 | 5 | ||
Mid-Atlantic |
1,879 | 4 | 4,374 | 6 | ||
South-Atlantic |
23,488 | 54 | 42,155 | 55 | ||
Midwest |
12,204 | 28 | 17,190 | 22 | ||
Mountain |
2,074 | 5 | 3,725 | 5 | ||
Pacific |
2,921 | 7 | 5,635 | 7 | ||
Unknown |
15 | 0 | 15 | 0 | ||
Anemia | 22,702 | 52 | 36,565 | 48 | <0.0001 | |
Hypertension | 41,247 | 94 | 73,342 | 96 | <0.0001 | |
Diabetes | 17,172 | 39 | 33,325 | 44 | <0.0001 | |
Peripheral vascular disease | 13,253 | 30 | 22,971 | 30 | 0.29 | |
Prior cerebrovascular or thromboembolic event | 14,127 | 32 | 23,472 | 31 | <0.0001 | |
Prior cerebrovascular event | 9,075 | 21 | 18,214 | 24 | <0.0001 | |
Stroke or TIA | 7,493 | 17 | 15,149 | 20 | <0.0001 | |
TIA | 5,850 | 13 | 11,603 | 15 | <0.0001 | |
Stroke | 3,547 | 8 | 7,969 | 10 | <0.0001 | |
Heart failure | 17,694 | 40 | 36,468 | 48 | <0.0001 | |
Kidney disease | 3,328 | 8 | 5,193 | 7 | <0.0001 | |
Dialysis | 1,498 | 3 | 2,398 | 3 | 0.006 | |
History of MI | 5,405 | 12 | 8,170 | 11 | <0.0001 | |
History of CABG | 6,529 | 15 | 10,639 | 14 | <0.0001 | |
CHA2DS2-VASC | <0.0001 | |||||
0–1 | 0 | 0 | 0 | 0 | ||
2 |
5,264 | 12 | 6,940 | 9 | ||
3 |
8,240 | 19 | 13,775 | 18 | ||
4 |
10,179 | 23 | 18,126 | 24 | ||
5 |
8,620 | 20 | 16,158 | 21 | ||
6 |
5,798 | 13 | 11,022 | 14 | ||
7 |
3,374 | 8 | 6,441 | 8 | ||
8 |
1,809 | 4 | 3,342 | 4 | ||
9 |
542 | 1 | 892 | 1 | ||
Mean |
5 | NA | 5 | NA | >0.99 | |
SD |
1.7 | NA | 1.6 | NA | ||
Atria score | <0.0001 | |||||
<= 3 (low) | 20,852 | 48 | 39,238 | 51 | ||
4 (intermediate) |
6,021 | 14 | 10,860 | 14 | ||
5 (high) |
16,953 | 39 | 26,598 | 35 | ||
Hospitalizations in the prior 6 months | 0.15 | |||||
0 | 37,382 | 85 | 65,791 | 86 | ||
1 |
5,007 | 11 | 8,476 | 11 | ||
2 |
1,032 | 2.4 | 1,743 | 2.3 | ||
≥3 |
405 | 0.9 | 686 | 0.9 |
OAC use at baseline was defined as any OAC use in the prior 12 months.