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. 2021 Jul 8;5:195–243. doi: 10.5414/ALX02257E

Consensus statements. Consensus statements.

Symptoms of an IgE-mediated food allergy are multifaceted and affect different organ systems (especially skin and oropharyngeal mucosa, gastrointestinal tract, respiratory tract, cardiovascular system). Strong consensus
For the diagnosis of food allergy, a clear and reproducible association of symptoms with the ingestion of defined foods and improvement of symptoms with avoidance, including in association with IgE sensitization on skin, blood or intestine, etc.
In blood or skin IgE-negative patients, local seronegative IgE-mediated allergic reactions are possible, among others.
Strong consensus
In cases of intermittent food tolerability a cofactor should be considered, e.g., cofactor-dependent food allergy such as exercise-induced analphylaxis. Consensus