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. 2021 Jul 8;5:195–243. doi: 10.5414/ALX02257E

Consensus statements. Consensus statements.

Oral food provocation (especially double-blind placebo-controlled) is the gold standard in the diagnosis of IgE-mediated food allergy. Strong consensus
If there is evidence of augmentation factors, these should be taken into account during provocation. Strong consensus
Food provocations should be performed when indicated to confirm or exclude allergy.
Provocation provides the basis for a safe food ingestion, allows counseling regarding appropriate allergen avoidance, and provides an assessment of the risk for severe reactions (anaphylaxis).
Consensus
A negative oral food provocation should be followed by repetitive cumulative administration of the tested food in an age- and daily-adapted amount no earlier than the next day to confirm clinical tolerance. Strong consensus
Oral food provocations should be performed in specialized facilities where emergency measures are immediately available. In addition, for provocation with a high risk of severe allergic reactions, intensive medical support should be available. Strong consensus