Table 3.
List of all neutropenia events
| Case | Week | Grade | Action for ADI-PEG 20 | Action for Pembrolizumab | Growth factors support (days) | Antibiotic (days) | Fever |
|---|---|---|---|---|---|---|---|
| D004 | 3 | 4 | Interrupted | Withdrew* | 3 | - | - |
| 14 | 3 | Interrupted | N/A | - | - | - | |
| 19 | 4 | Interrupted | N/A | 1 | - | - | |
| 22 | 3 | Interrupted | N/A | - | - | - | |
| 26 | 3 | Interrupted | N/A | - | - | - | |
| D006 | 3 | 4 | - | - | 2 | - | - |
| D007 | 3 | 4 | Interrupted | Interrupted | - | - | - |
| D009 | 3 | 3 | - | - | - | - | - |
| D012 | 3 | 3 | - | - | 3 | - | - |
| D013 | 4 | 4 | Interrupted | Interrupted | 2 | 7 | +** |
| D014 | 3 | 4 | Interrupted | Interrupted | 1 | 7 | +** |
| B001 | 2 | 3 | - | - | 1 | - | - |
| B015 | 5 | 3 | Interrupted | Interrupted | 1 | - | - |
| B022 | 3 | 4 | Interrupted | - | 5 | 8 | +** |
*Pembrolizumab withdrew because of DLT (Grade 3 hepatitis).
**The events were also graded as Grade 3 febrile neutropenia.