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. 2021 Jun 29;11:641428. doi: 10.3389/fonc.2021.641428

Figure 1.

Figure 1

CTLA-4 and PDL-1 ligation interferes with glucose metabolism in activated T cells. The ligation of PD-1 blocks the activation of PI3K and consequently the Akt signalling pathway resulting the inhibition of glycolysis. CTLA-4 accomplishes the same outcome by activating the phosphatase PP2A.