TABLE 3.
Multivariate analysis of clinicopathological characteristics affecting breast cancer-specific survival and disease-free survival in luminal A and triple-negative breast cancers.
| Parameter | Breast cancer-specific survival | Disease-free survival | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | |
| Luminal A subtype (n = 303) | ||||
| SASP, present vs absent | 2.884 (1.204–6.909) | 0.017 | 3.119 (1.731–5.618) | <0.001 |
| LVI, present vs absent | - | - | - | |
| Lymph node metastasis, present vs absent | - | - | 1.982 (1.072–5.618) | 0.029 |
| Histologic grade, 3 vs 1 and 2 | - | - | ||
| Tumor size, >2 cm vs ≤ 2 cm | 11.031 (3.262–37.311) | <0.001 | - | - |
| Triple-negative subtype (n = 247) | ||||
| SASP, present vs absent | 0.355 (0.167–0.757) | 0.007 | 0.437 (0.215–0.889) | 0.022 |
| LVI, present vs absent | - | - | 4.66 (2.164–10.035) | <0.001 |
| Lymph node metastasis, present vs absent | 4.203 (1.891–9.342) | <0.001 | - | - |
| iCD103 + lymphocyte, high (≥ 38/ mm2) vs low (< 38/ mm2) | 0.412 (0.178–0.954) | 0.038 | ||
| Stromal TILs,> 5% vs ≤ 5% | - | - | 0.444 (0.222–0.888) | 0.022 |
CI, confidence interval; iCD103 + lymphocyte, intraepithelial CD103-positive lymphocyte; LVI, Lymphovascular invasion; SASP, senescence-associated secretory phenotype; TILs, tumor-infiltrating lymphocytes.