Table 1.
Fold selectivity of PDE7 inhibitors against members of the PDE family
| PDE | OMSPDE71 | OMSPDE79 |
|---|---|---|
| 1B | >1235 | >562 |
| 2A | 1713 | 1400 |
| 3A | >1235 | 1744 |
| 4A | >100 | >100 |
| 5A | 2569 | 1106 |
| 7A | 1 | 1 |
| 8A | 4104 | >562 |
| 9A | >1235 | >562 |
| 10A | 212 | >562 |
| 11A | >1235 | >562 |
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