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. 2021 Jul 13;3(3):zcab029. doi: 10.1093/narcan/zcab029

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© The Author(s) 2021. Published by Oxford University Press on behalf of NAR Cancer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — VEGFA isoforms and +157 enhancer region. (A) Schematic representation of the VEGFA gene and four of its known isoforms. Rectangles: exons, black lines: introns. Arrows in black indicate primers for isoform VEGFA₁₂₁ and arrows in red for VEGFA₁₈₉. (B) ChIP-seq tracks for H3K27ac and H3K4me1 including DHS and Hi-C data (5 kb resolution) at the VEGFA locus in K562 cells. VEGFA +157 enhancer is depicted with a black arrow and enriched for H3K27ac and H3K4me1. The Hi-C data suggest a sub-TAD between VEGFA +157 enhancer and the promoter, marked with a black box. Green arrows depict additional enhancers with sub-TADs to VEGFA promoter.