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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Bioorg Med Chem Lett. 2021 May 26;45:128137. doi: 10.1016/j.bmcl.2021.128137

Scheme 2.

Scheme 2.

Synthesis of the cytidine nucleotide 12. Reagents and conditions: a. (i) dioxane, DMAP, TEA, 2,4,6-triisopropylbenzenesulfonyl chloride, rt, 18 h; (ii) NH2NHCOOMe, rt, 18 h; (iii) 1 N NH3 in methanol, rt, 18 h, 6%; b. (i) PO(OMe)3, Proton Sponge®, POCl3, 0 °C, 2 h; (ii) DMF, 2[Bu3NH]+HPO42−, 0 °C → rt, 15 min, 5.3%.