Table 2.
Physicochemical Properties of AMD-Loaded PLGA50 Nanoparticles, Each Formulation Contains 2% PLGA50 and 0.2% AMD, (Mean ± SD; n=3)
| Formulation Code | PS (nm) | PDI | ZP (mV) | EE% | LC% | Y% |
|---|---|---|---|---|---|---|
| NP1 | 175.93±1.75 | 0.10±0.04 | −16.30±0.66 | 89.46±4.29 | 16.30±1.42 | 85.91±7.59 |
| NP2 | 199.37±2.33 | 0.12±0.01 | −14.88±1.14 | 88.12±1.85 | 12.22±1.10 | 78.86±6.73 |
| NP3 | 217.37±3.21 | 0.13±0.02 | −15.47±1.36 | 84.69±2.62 | 11.46±0.75 | 72.88±8.19 |
| NP4 | 185.80±1.57 | 0.09±0.01 | −16.67±1.10 | 95.86±2.24 | 18.08±0.78 | 88.93±5.76 |
| NP5 | 189.33±1.58 | 0.14±0.04 | −12.70±0.62 | 93.25±3.88 | 11.26±0.75 | 75.53±6.62 |
| NP6 | 202.07±0.23 | 0.18±0.02 | −15.20±1.14 | 84.89±2.80 | 9.46±0.59 | 71.64±7.49 |
Abbreviations: EE%, percent entrapment efficiency; LC%, percent loading capacity; PDI, polydispersity index; PS, particle size; Y%, percent yield; ZP, zeta potential.