Table 4.

Release Kinetics of in vitro Release Data

Release Media	Model	Formulation Code
		AMD	NP1	NP4
Simulated gastric pH	Zero	0.7262	N/A	0.7680
	First	0.7373	N/A	0.7881
	Higuchi	0.9376	N/A	0.9634
	Release order	Diffusion		Diffusion
	K-P
	r2	0.8338	N/A	0.9429
	N	0.38	N/A	0.33
	Mechanism	Fickian	---	Fickian
Simulated intestinal pH	Zero	0.9674	0.5442	0.9479
	First	0.9854	0.5547	0.9560
	Higuchi	0.9669	0.8350	0.9822
	Release order	Dissolution	Diffusion	Diffusion
	K-P
	r2	0.9822	0.6238	0.8920
	N	0.78	0.15	0.62
	Mechanism	Non-Fickian	Fickian	Non-Fickian
Physiological pH	Zero	0.5854	0.8286	0.8966
	First	0.6118	0.8404	0.9254
	Higuchi	0.7147	0.8694	0.9461
	Release order	Diffusion	Diffusion	Diffusion
	K-P
	r2	0.8186	0.8894	0.9588
	N	0.20	0.14	0.23
	Mechanism	Fickian	Fickian	Fickian

Notes: The underlined values are the highest r² of each formula at the specified pH value.

Abbreviations: K-P, Korsmeyer–Peppas model; n, the diffusion exponent; r², correlation coefficient; N/A, not applicable.