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. 2021 Jul 13;2021(7):CD009434. doi: 10.1002/14651858.CD009434.pub2

Yilmaz 2014.

Study characteristics
Methods Study type: RCT (split‐mouth design, 3 groups)
Duration of trial: not mentioned
Duration of follow‐up: immediately after treatment
Participants Inclusion criteria: patients with 3 sensitive teeth with VAS score of at least 4, Miller Class III mobility and were indicated to extraction
Exclusion criteria: patients with carious lesions in selected or neighboring teeth, defective restoration; patients who had undergone professional desensitizing therapy during the previous 6 months or using desensitizing toothpaste in last 3 months; patients being under analgesics/anti‐inflammatory drugs at time of study, pregnancy or smoking
Total number: 20 participants with 60 teeth
Age range: 18 to 60 years
Sex (M/F): 8/12
Interventions Group 1: Er,Cr:YSGG laser (025 W, 44 J/cm2)
Group 2: Er,Cr:YSGG laser (05 W, 89 J/cm2)
Details: 2780 nm wavelength Er,Cr:YSGG laser was applied 30 s to Groups 1 and 2 in the hard tissue mode with the MZ6 tip (600 mm diameter, 6 mm length) using non‐contact mode at repetition rate of 20 pulses s1 and pulse duration of 140 ms, 0% water and 10% air
Group 3: same Er,Cr:YSGG laser without laser emission was used
Outcomes Responses to evaporative stimuli (air blast) (VAS) was assessed immediately after treatment
Notes Baseline characteristics: each patient evaluated the perception of discomfort after the application of an air blast for 3 s at a distance of approximately 1 cm and at right angle to the buccal site of the assigned teeth. The adjacent teeth were isolated with cotton rolls to prevent false‐positive results; all stimuli were given by 1 operator in the same dental chair with the same equipment yielding similar air pressure (55 to 60 psi) and air temperature (21 to 22 °C) each time; after the stimulus, the patient was asked to record their overall sensitivity on a VAS
Sample size calculation: the power analysis was conducted based on this minimum clinically significant difference in VAS scores, using alpha at level 005, at 80% power and a r of 07
Source of funding: this research was carried out without funding
Ethics approval: quote: "Study protocol and related consent forms were approved by the Institutional Review Board and Ethics committee of Near East University"
Informed consent: quote: "Following verbal information about the treatment plan, possible discomforts and potential risks, the subjects who signed the informed consent form were included in the study"
Adverse events: none
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Lottery method was used
Quote: "A unique number attended to the each treatment method and these numbers were put in a bowl, mixed"
Allocation concealment (selection bias) Low risk Quote: "A unique number attended to the each treatment method and these numbers were put in a bowl, mixed and then, without looking, the researcher selected numbers for each tooth"
Blinding of participants and personnel (performance bias)
All outcomes Low risk Quote: "The patients did not know what kind of therapy each tooth was receiving"
Blinding of outcome assessment (detection bias)
All outcomes Low risk Quote: "The effectiveness of all treatments was assessed at immediately after treatment by one calibrated examiner who was not aware of the type of treatment applied"
Incomplete outcome data (attrition bias)
All outcomes Low risk No loss to follow‐up
Selective reporting (reporting bias) Low risk All intended outcomes were reported in study
Other bias Low risk No other sources of bias were identified
Sample size calculation, source of funding and ethics approval were mentioned in the study

CPP‐ACPF = casein phosphopeptide amorphous calcium phosphate; CSP = calcium sodium phosphosilicate; DH = dentinal hypersensitivity; Er,Cr:YSGG = erbium,chromium:yttrium‐scandium‐gallium‐garnet; GaAIAs = gallium‐aluminum‐arsenide; J = Joules; LLLT = low‐level laser therapy; M/F = male/female; mW = milliwatt; NaF = sodium fluoride; n‐CAP = nano‐carbonate apatite; Nd:YAG = neodymium‐doped:yttrium‐aluminum‐garnet; nHAP = nano‐hydroxyapatite; nm = nanometer; PBM = photobiomodulation; RCT = randomized controlled trial; s = second; SD = standard deviation; VAS = visual analogue scale; VRS = verbal rating score.