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. 2021 Jul 13;16(7):e0254640. doi: 10.1371/journal.pone.0254640

Table 2. Univariate logistic regression analysis of each factor associated with mortality and critical condition.

On admission status Mortality Critical condition
OR AUC p value OR AUC p value
(95% CI) (95% CI)
Plasma PCR 18.75 0.7851 0.002 72.0000 0.8198 <0.001
(positive to negative) (3.9168–89.7584) (12.9830–399.2905)
Sex (female to male) 4.1481 0.6707 0.048 1.5680 0.5533 0.403
(0.9633–17.8618) (0.5503–4.4677)
Age (years) 1.1835 0.9412 <0.001 1.0853 0.8247 <0.001
(1.0695–1.3097) (1.0410–1.1315)
LDH (U/L) 1.0049 0.6633 0.098 1.0091 0.7508 <0.001
(0.9992–1.0107) (1.0039–1.0143)
CRP (mg/dL) 1.0697 0.6968 0.196 1.1162 0.7455 0.007
(0.9686–1.1814) (1.0292–1.2107)
D-dimer (μg/mL) 1.5524 0.8889 <0.001 1.3244 0.7734 0.004
(1.0707–2.2509) (0.9882–1.7748)
Ferritin (ng/mL) 1.0002 0.5890 0.664 1.0006 0.6343 0.036
(0.9994–1.0009) (1.0000–1.0012)
Absolute lymphocyte count (/μL) 0.9987 0.6827 0.108 0.9990 0.6201 0.094
(0.9970–1.0004) (0.9978–1.0002)
Ct value of the
nasopharyngeal PCR
0.6767 0.8656 <0.001 0.6698 0.8849 <0.001
(0.5029–0.9106) (0.5080–0.8833)
4C Mortality Score 1.7441 0.9532 <0.001 1.5507 0.8983 <0.001
(1.2694–2.3964) (1.2610–1.9069)
CURB-65 4.5482 0.9244 <0.001 3.6584 0.8465 <0.001
(2.0303–10.1889) (2.0649–6.4816)
A-DROP 4.4331 0.9351 <0.001 3.7778 0.8904 <0.001
(2.0729–9.4803) (2.1474–6.6462)

Abbreviations: OR, odds ratio; CI, confidence interval; AUC, area under the receiver operating characteristic curve; LDH, lactate dehydrogenase; CRP, C-reactive protein.