Table 4. Multivariable Cox proportional hazards regression analysis of factors associated with mortality.

Variable	HR	95% CI	p value	Optimism adjusted HR	Optimism adjusted 95% CI
Age	1.05	1.00–1.08	0.003	1.04	0.99–1.09
Diabetes	1.13	0.46–2.77	0.79	1.43	0.77–2.36
Obesity	2.33	1.03–5.26	0.04	2.35	1.29–4.23
White blood cells, x 109/L	1.25	0.89–1.75	0.20	1.26	0.77–2.06
High-sensitivity C-reactive protein, mg/L	1.03	0.99–1.06	0.08	1.02	1.02–1.07
Procalcitonin	1.03	1.01–1.06	0.04	1.03	0.87–1.22
SOFA	1.37	1.11–1.69	0.003	1.40	0.99–1.99
Neutrophils, x 109/L	0.79	0.54–1.14	0.21	0.78	0.46–1.32
Urea, mg/dL	1.01	0.99–1.02	0.06	1.01	0.99–1.02
Lactate	0.98	0.96–1.01	0.28	0.99	0.95–1.04
PaO2/FiO2	0.88	0.86–0.99	0.003	0.87	0.84–0.98