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C39 and CLD domains in AMS/PCAT transporters. (A) Structure of the catalytically active C39 domain from PCAT1 (based on PDB ID 6V9Z).505 The main elements of the secondary structure, as well as the key catalytic residues are highlighted. (B) The structure of the C39-like domain (CLD) of the HlyB transporter in identical orientation based on PBD ID 3ZUA.506 While the general architecture is preserved, the active site cysteine residue is substituted by a tyrosine.
