Figure 19.

Structural organization of MacB. (A) General topology of the single MacB protomer highlighting the N-terminal nucleotide binding domain (NBD; magenta), the connecting helix (CoH), the transmembrane domain (TM domain) with its four helices, as well as the periplasmic core domain (PCD), which is composed of a PD-module and a SABRE subdomain (green). CH1 and CH2, coupling helices 1 and 2, respectively. (B) Two orthogonal orientations of the single protomer of MacB from A. baumanii based on PDB ID 5WS4,²⁴ highlighting the principal secondary structure elements. The blue oval delineates the PD. (C) View of the complete MacB-dimer.