Figure 34.

Structural organization of a typical PAP based on the structure of the MexA from Pseudomonas aeruginosa (PDB ID 6TA5).²⁷⁰ The topological organization of the principal PAP domains is shown on the right. The polypeptide chain of the PAP has a form with a hairpin-like fold with both N- and C-termini being close to the membrane and both the N- and C-terminal parts of the protein contributing to each domain. The N-terminal cys-residue that is lipidated in the RND-associated PAPs is highlighted in yellow.