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AcrBZ co-structure. The asymmetric AcrB trimer (gray cartoon) with the three protomers in the L (loose), T (tight), and O (open) conformations. The auxiliary transmembrane modulator AcrZ (raspberry cartoon) is located at the surface periphery on each of the AcrB protomers at the transmembrane domain. The X-ray structure display (PDB: 5NC5) was solved in complex with DARPins (not shown) and puromycin (PUY, orange spheres).
