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Drug binding to the DBP of the AcrB T conformer. Superimposition of the coordinates of minocycline (MIN, carbon = green; PDB: 4DX5), doxorubicin (DOX, carbon = violet; PDB: 4DX7), rhodamine 6G (R6G, carbon = pink; PDB: 5ENS), and puromycin (PUY, carbon = orange; PDB: 5NC5) in the DBP. Substrates are shown as sticks, the PN2/PC1 subdomains are represented as a cartoon, colored in yellow. The switch-loop is highlighted in green.
