Table 2. List of Tripartite Systems That When Deleted or Inactivated Result in Attenuated Virulence in Their Cell/Host Model of Infectiona.
| Microorganism | Efflux pump family | Efflux system | Cell/host infection model | ref(s) |
|---|---|---|---|---|
| S. Typhimurium | RND | AcrAB-TolC | Human epithelial cells, murine macrophages, Galleria mellonella, mouse, chicken | (101, 158−160) |
| MdtABC | Mouse | (101) | ||
| MdsABC | Mouse | (101) | ||
| ABC | MacAB-TolC | Mouse | (101, 138, 139) | |
| SiiCDF | Cattle and bovine enterocytes | (156) | ||
| K. pneumoniae | RND | AcrAB-TolC | Mouse | (51) |
| E. coli | ABC | MacAB-TolC | Galleria mellonella and murine mammary glands | (161) |
| RND | MdtB | Mouse spleen | (161) | |
| MdtEF | Human macrophages | (162) | ||
| A. baumannii | RND | AdeABC | Galleria mellonella | (163) |
| AdeIJK | Caenorhabditis elegans | (164) | ||
| E. cloacae | RND | AcrAB-TolC | Mouse | (165) |
| F. tularensis | RND | AcrAB | Mouse | (166) |
| N. gonorrhoeae | RND | MtrCDE | Human neutrophils, mouse | (146, 167) |
| P. aeruginosa | RND | MexAB-OprM | Mouse, canine epithelial cells | (168) |
| MexGHI-OpmD | Rat | (83) | ||
| S. maltophilia | RND | SmeYZ | Mouse | (114) |
| B. pseudomallei | RND | BpeAB-OprB | Human epithelial cells and macrophages | (169) |
| B. burgdorferi | RND | BesABC | Mouse | (32) |
| C. jejuni | RND | CmeABC | Acanthamoeba polyphaga, Chicken | (170) |
| (143) | ||||
| S. flexneri | MFS | EmrKY | Human macrophages | (144) |
| L. pneumophila | ABC | LssBD-TolC | Ameoba and human macrophages | (157) |
| V. cholerae | RND | VexAB-TolC, VexCD-TolC, VexIJK | Mouse | (120) |
| Riemerella anatipestifer | RND | RaeEF-RopN | Duck | (99) |
| E. amylovora | RND | MdtABC | Apple rootstock | (147) |
| MdtUVW | ||||
| AcrAB | (171) | |||
| R. solanacearum | RND | AcrAB | Tomato plant | (148) |
a
ABC, ATP-binding cassette; MFS, major facilitator superfamily; RND, resistance-nodulation-division.