Table 2.
Factors (aOR and 95%CI) associated with recent COVID-19 in France (February – May 2021) by virus type among 41151 cases compared to 3644 controls.
| Original virus (n=7288) | B.1.1.7 lineage (n=31313) | B.1.351/P1 lineages (n=2550) | ||||
|---|---|---|---|---|---|---|
| OR (95% CI)* | aOR (95%CI)⁎⁎ | OR (95% CI)* | aOR (95%CI)⁎⁎ | OR (95% CI)* | aOR (95%CI)⁎⁎ | |
| Body mass index (in kg/m2) | ||||||
| <18·5 | 1 (ref·) | 1 (ref) | 1 (ref·) | 1 (ref) | 1 (ref·) | 1 (ref) |
| ≥18·5 & <25 | 1·12 (1·02-1·24) | 1·09 (0·98-1·20) | 0·99 (0·91-1·08) | 1·00 (0·92-1·09) | 1·01 (0·90-1·15) | 1·03 (0·91-1·17) |
| ≥25 | 1·04 (0·93-1·17) | 1·05 (0·93-1·19) | 0·90 (0·81-1·00) | 0·99 (0·89-1·10) | 0·90 (0·77-1·04) | 0·98 (0·84-1·14) |
| High blood pressure | ||||||
| No | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) |
| Yes | 0·79 (0·68-0·93) | 0·80 (0·68-0·95) | 0·78 (0·69-0·90) | 0·85 (0·74-0·98) | 0·79 (0·65-0·97) | 0·86 (0·69-1·06) |
| Diabetes | ||||||
| No | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) |
| Yes | 0·79 (0·61-1·02) | 0·79 (0·61-1·03) | 0·67 (0·54-0·83) | 0·74 (0·59-0·92) | 0·73 (0·52-1·03) | 0·79 (0·56-1·13) |
| Chronic respiratory disease | ||||||
| No | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) |
| Yes | 1·21 (1·03-1·43) | 1·24 (1·05-1·47) | 1·17 (1·02-1·36) | 1·25 (1·08-1·45) | 1·24 (1·01-1·51) | 1·31 (1·07-1·61) |
| History of myocardial infarction / angina pectoris | ||||||
| No | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) |
| Yes | 1·35 (0·80-2·28) | 1·36 (0·79-2·34) | 1·13 (0·71-1·79) | 1·22 (0·75-1·97) | 1·01 (0·49-2·08) | 1·06 (0·51-2·22) |
| Education | ||||||
| No diploma | 1 (ref·) | 1 (ref) | 1 (ref·) | 1 (ref) | 1 (ref·) | 1 (ref) |
| Pre-bachelor degree | 0·52 (0·38-0·72) | 0·53 (0·38-0·73) | 0·66 (0·49-0·89) | 0·67 (0·50-0·91) | 0·58 (0·39-0·86) | 0·58 (0·39-0·86) |
| Undergraduate degree | 0·39 (0·28-0·53) | 0·39 (0·28-0·53) | 0·58 (0·43-0·78) | 0·58 (0·43-0·78) | 0·51 (0·34-0·75) | 0·50 (0·34-0·74) |
| Graduate degree | 0·34 (0·25-0·46) | 0·33 (0·24-0·46) | 0·61 (0·45-0·81) | 0·60 (0·45-0·80) | 0·54 (0·37-0·80) | 0·53 (0·36-0·77) |
| Post-graduate degree | 0·40 (0·29-0·55) | 0·42 (0·30-0·57) | 0·91 (0·68-1·23) | 0·93 (0·69-1·26) | 0·78 (0·53-1·15) | 0·78 (0·53-1·16) |
| Housing type | ||||||
| House | 1 (ref·) | 1 (ref) | 1 (ref·) | 1 (ref) | 1 (ref·) | 1 (ref) |
| Apartment | 0·88 (0·80-0·98) | 1·01 (0·91-1·12) | 0·76 (0·70-0·83) | 0·90 (0·82-0·99) | 0·77 (0·68-0·87) | 0·87 (0·76-0·99) |
| Long term care facility and social housing | 1·21 (0·67-2·20) | 1·26 (0·69-2·30) | 0·87 (0·50-1·51) | 0·95 (0·55-1·66) | 1·18 (0·57-2·44) | 1·30 (0·62-2·69) |
| Number of persons in the household | ||||||
| 1 | 1 (ref·) | 1 (ref) | 1 (ref·) | 1 (ref) | 1 (ref·) | 1 (ref) |
| 2 | 1·07 (0·95-1·21) | 1·02 (0·90-1·16) | 1·18 (1·06-1·31) | 1·10 (0·98-1·23) | 1·11 (0·94-1·30) | 1·02 (0·87-1·21) |
| 3 | 1·37 (1·19-1·57) | 1·07 (0·92-1·25) | 1·56 (1·39-1·76) | 1·21 (1·05-1·38) | 1·44 (1·21-1·71) | 1·08 (0·89-1·32) |
| 4 | 1·67 (1·46-1·92) | 1·20 (1·01-1·43) | 2·03 (1·80-2·29) | 1·41 (1·21-1·64) | 1·75 (1·47-2·09) | 1·17 (0·94-1·46) |
| 5 | 1·79 (1·49-2·16) | 1·22 (0·98-1·52) | 1·97 (1·67-2·31) | 1·33 (1·10-1·61) | 1·64 (1·30-2·07) | 1·06 (0·80-1·40) |
| 6+ | 3·17 (2·28-4·41) | 2·12 (1·49-3·02) | 3·10 (2·29-4·21) | 2·19 (1·58-3·02) | 2·38 (1·59-3·54) | 1·59 (1·04-2·43) |
| Child in household attending daycare centre or looked after by a childminder | ||||||
| No | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) |
| Yes | 2·02 (1·66-2·46) | 1·89 (1·55-2·32) | 2·12 (1·77-2·54) | 1·84 (1·53-2·22) | 2·10 (1·68-2·63) | 1·89 (1·50-2·39) |
| Child in household attending school | ||||||
| No | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) |
| Yes | 1·68 (1·53-1·85) | 1·43 (1·26-1·63) | 1·74 (1·60-1·89) | 1·41 (1·26-1·58) | 1·64 (1·45-1·85) | 1·46 (1·24-1·71) |
| Health care worker | ||||||
| No | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) |
| Yes | 2·19 (1·87-2·56) | 2·80 (2·37-3·31) | 1·66 (1·44-1·92) | 2·10 (1·80-2·45) | 1·90 (1·58-2·30) | 2·33 (1·91-2·85) |
| History of past infection | ||||||
| No | 1 (ref·) | 1 (ref) | 1 (ref·) | 1 (ref) | 1 (ref·) | 1 (ref) |
| Indicated by virological test (>6 months) | 0·25 (0·13-0·46) | 0·24 (0·13-0·46) | 0·15 (0·10-0·24) | 0·16 (0·10-0·25) | 0·26 (0·11-0·59) | 0·26 (0·11-0·59) |
| Indicated by virological test (between 2 and 6 months) | 0·18 (0·13-0·25) | 0·17 (0·12-0·24) | 0·12 (0·09-0·16) | 0·12 (0·09-0·15) | 0·18 (0·11-0·30) | 0·17 (0·10-0·29) |
| Indicated by serological test | 0·35 (0·14-0·86) | 0·31 (0·12-0·76) | 0·57 (0·30-1·11) | 0·51 (0·26-0·99) | 0·79 (0·30-2·08) | 0·69 (0·26-1·81) |
| Suspected by clinician | 0·60 (0·38-0·96) | 0·61 (0·38-0·97) | 0·70 (0·48-1·03) | 0·70 (0·48-1·03) | 0·65 (0·37-1·17) | 0·65 (0·36-1·17) |
| History of vaccination⁎⁎⁎ | ||||||
| Not vaccinated | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) | 1 (ref·) |
| Yes, completely vaccinated | 0·19 (0·12-0·29) | 0·12 (0·08-0·19) | 0·20 (0·15-0·26) | 0·14 (0·10-0·19) | 0·35 (0·22-0·55) | 0·23 (0·14-0·37) |
⁎
Adjusted for the matching variables (age, sex, region, population density and calendar week)
⁎⁎
Adjusted for the matching and all other variables (age, sex, region and agglomeration density of residence, calendar week, body mass index, high blood pressure, diabetes, history of chronic respiratory disease, history of myocardial infarction and angina pectoris, education, housing type, number of people living in the household, number of children attending daycare or school, working as health care worker or not, and past history of infection)
⁎⁎⁎
Participants with only one dose of vaccine, or within seven days of second dose, were excluded for this analysis