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. 2021 Jul 8;134(13):jcs258321. doi: 10.1242/jcs.258321

Fig. 5.

Fig. 5.

Inhibition of FAK autophosphorylation prevents furrow formation and the associated cell shape changes. (A) Optogenetic activation of RhoA after 30 min incubation with 10 µM FAK inhibitor FAKi14. Cell is expressing LARG-mTurq-SspB, iLID-CaaX, H2B-mCh (red) and Venus-KRasCT (green). Data are representative of 10 out of 10 cells. (B) Optogenetic activation of RhoA in fascin-overexpressing cells after 30 min incubation with 10 µM FAKi14. Cell is expressing LARG-mTurq-SspB, iLID-CaaX, fascin-mCh (red) and Venus-H2B (green). Data are representative of 23 out of 30 cells. Rectangles represent the area of photoactivation. Scale bars: 10 μm. Time is in min:s.