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. 2021 Jul 8;134(13):jcs258321. doi: 10.1242/jcs.258321

Fig. 6.

Fig. 6.

Inhibition of fascin-mediated actin bundling prevents furrow formation and the associated cell shape changes. (A) Optogenetic activation of RhoA after 30 min incubation with 40 µM fascin inhibitor G2. Cell is expressing LARG-mTurq-SspB, iLID-CaaX, H2B-mCh (red) and Venus-KRasCT (green). Data are representative of 10 out of 10 cells. (B) Optogenetic activation of RhoA in FAK-overexpressing cells after 30 min incubation with 40 µM G2. Cell is expressing LARG-mTurq-SspB, iLID-CaaX, FAK-mCh and Venus-H2B (green). Data are representative of 28 out of 35 cells. Rectangles represent the area of photoactivation. Scale bars: 10 μm. Time is in min:s.