TABLE 1.

Genes up-regulated and down-regulated in the cerebral cortex (CC), cerebellum (CE), and hippocampus (HPC) of rats in the VPA-treated group.

Brain region	Target	Samples	Average of relative normalized gene expression	SEM	Regulation FC (fold changes)	Compared to Regulation Threshold (FC < −4 down-regulated, FC > 4 up-regulated)
CC	Adra1d	Control	1.00	0.22	7.12	Up-regulated
		VPA	7.12	9.34
	Adra2a	Control	1.00	0.12	59.61	Up-regulated
		VPA	59.60	78.12
	Chrna5	Control	1.00	0.15	4.07	Up-regulated
		VPA	4.07	5.33
	Chrna7	Control	1.00	0.15	119.63	Up-regulated
		VPA	119.63	156.9
	Chrne	Control	1.00	0.13	−4.44	Down-regulated
		VPA	0.23	0.30
	Drd2	Control	1.00	0.19	−5.33	Down-regulated
		VPA	0.19	0.30
CE	Adra1a	Control	1.00	0.79	−5.20	Down-regulated
		VPA	0.19	0.18
	Adra1d	Control	1.00	1.09	−9.52	Down-regulated
		VPA	0.11	0.10
	Adcy7	Control	1.00	0.48	−4.21	Down-regulated
		VPA	0.24	0.36
	Chrm1	Control	1.00	2.39	−18.70	Down-regulated
		VPA	0.05	0.05
	Chrm4	Control	1.00	1.94	−8.29	Down-regulated
		VPA	0.12	0.06
	Chrna5	Control	1.00	2.69	−13.32	Down-regulated
		VPA	0.08	0.03
	Chrna7	Control	1.00	1.02	−5.15	Down-regulated
		VPA	0.19	0.12
	Drd1a	Control	1.00	0.27	−7.49	Down-regulated
		VPA	0.13	0.06
HPC	Htr1b	Control	1.00	0.66	−11.23	Down-regulated
		VPA	0.09	0.11
	Htr1d	Control	1.00	0.47	−4.29	Down-regulated
		VPA	0.23	0.13
	Htr3a	Control	1.00	0.66	−11.81	Down-regulated
		VPA	0.09	0.11