TABLE 2.
Genes up-regulated and down-regulated in the cerebral cortex (CC), cerebellum (CE), and hippocampus (HPC) of rats in the THAL-treated group.
| Brain region | Target | Samples | Average of relative normalized gene expression | SEM | Regulation FC (fold changes) | Compared to Regulation Threshold (FC < −4 down-regulated, FC > 4 up-regulated) |
| CC | Adra2a | Control | 1.00 | 0.12 | 5.02 | Up-regulated |
| THAL | 5.02 | 1.05 | ||||
| Adrb3 | Control | 1.00 | 0.15 | −28.63 | Down-regulated | |
| THAL | 0.04 | 0.02 | ||||
| Adrbk1 | Control | 1.00 | 0.19 | −5.98 | Down-regulated | |
| THAL | 0.17 | 0.04 | ||||
| Chrm5 | Control | 1.00 | 0.45 | −7.49 | Down-regulated | |
| THAL | 0.13 | 0.03 | ||||
| Chrna7 | Control | 1.00 | 0.15 | 5.66 | Up-regulated | |
| THAL | 5.66 | 0.73 | ||||
| Chrne | Control | 1.00 | 0.13 | −67.59 | Down-regulated | |
| THAL | 0.02 | 0.01 | ||||
| Drd2 | Control | 1.00 | 0.19 | −15.81 | Down-regulated | |
| THAL | 0.06 | 0.01 | ||||
| Drd5 | Control | 1.00 | 0.12 | −26.94 | Down-regulated | |
| THAL | 0.04 | 0.01 | ||||
| CE | Adra1d | Control | 1.00 | 1.09 | −9.71 | Down-regulated |
| THAL | 0.10 | 0.18 | ||||
| Chrm1 | Control | 1.00 | 2.39 | −11.70 | Down-regulated | |
| THAL | 0.09 | 0.13 | ||||
| Chrm4 | Control | 1.00 | 1.94 | −12.13 | Down-regulated | |
| THAL | 0.13 | 0.07 | ||||
| Chrna4 | Control | 1.00 | 0.85 | −7.74 | Down-regulated | |
| THAL | 0.13 | 0.26 | ||||
| Chrna7 | Control | 1.00 | 1.02 | −6.79 | Down-regulated | |
| THAL | 0.15 | 0.24 | ||||
| Drd1a | Control | 1.00 | 1.09 | −15.35 | Down-regulated | |
| THAL | 0.19 | 0.53 | ||||
| Htr1f | Control | 1.00 | 0.27 | −4.66 | Down-regulated | |
| THAL | 1.07 | 0.11 | ||||
| HPC | Htr1b | Control | 1.00 | 1.67 | −10.89 | Down-regulated |
| THAL | 0.09 | 0.12 | ||||
| Htr1d | Control | 1.00 | 1.19 | −55.24 | Down-regulated | |
| THAL | 0.02 | 0.04 | ||||
| Htr3a | Control | 1.00 | 1.67 | −9.71 | Down-regulated | |
| THAL | 0.10 | 0.14 |