Figure 4.

Mean avexitide plasma concentration by dosing regimen: avexitide 30 mg twice daily; light blue/solid line, and avexitide 60 mg once daily; dark blue/dashed line on Days 29 and 43. On each of Days 29 and 43, a trough PK sample was collected immediately before the T = −90 minute injection of study drug. T = 0 minutes represents the start of Ensure Compact drink consumption. T = 0, 60, and 180 PK samples were collected at the same time as the plasma glucose and hormonal (insulin, C-peptide, GLP-1, glucagon) draws with PK sampling additionally obtained at T = 330 minutes.