Table 4.

Estimated changes from baseline in muscle performance and physical function outcomes by treatment arm

Variable	Placebo	1 mg/day	5 mg/day	15 mg/day	P value (5 mg/day vs Placebo)	P value (any effect)
Gait speed in 6-minute walk, m/sec	0.06 (0.02, 0.10)	0.08 (0.04, 0.13)	0.09 (0.05, 0.12)	0.06 (−0.001, 0.12)	0.32	0.71
Unloaded 50m walk gait speed, m/sec	0.06 (−0.01, 0.12)	0.13 (0.05, 0.20)	0.03 (−0.03, 0.09)	0.08 (−0.03, 0.19)	0.52	0.26
Loaded 50m walk gait speed, m/sec	0.05 (−0.02, 0.12)	0.12 (0.03, 0.20)	0.05 (−0.02, 0.12)	0.11 (0.001, 0.22)	0.93	0.44
Unloaded stair climb power, watts	7.2 (−35.2, 49.5)	26.6 (−26.1, 79.2)	0.14 (−40.5, 40.7)	45.0 (−26.8, 116.9)	0.80	0.65
Loaded stair climb power, watts	10.9 (−31.7, 53.5)	−6.6 (−59.2, 45.9)	−6.8 (−54.1, 40.6)	72.2 (2.99, 141.4)	0.56	0.25
Leg press 1-RM, N	7.5 (−87.9, 102.9)	138.6 (17.9, 259.3)	55.6 (−28.0, 139.2)	98.9 (−35.6, 233.5)	0.44	0.30

The data are point estimates and 95% CIs extracted from mixed model framework. P values for overall and for prespecified comparison of 5-mg vs placebo.

Abbreviation: 1-RM, one repetition maximum in Newtons.