Figure 1.

Matching Methodology: Illustrative Example. (a) Pre-match: data from treated patients span from their date of treatment initiation (ie, their index date) to the end of data availability while data from metreleptin-naïve patients span from the date of first available data to the end of data availability. An index date analogous to the treatment initiation date needs to be defined for records from metreleptin-naïve patients before they can be directly compared to a treated patient. (b) Post-match: the index date for the matched record from metreleptin-naïve patient is defined as the date where the patient was most similar to the treated patient on their date of treatment initiation. Data from this matched record now span from this index date to the end of data availability. The unmatched metreleptin-naïve patient is returned to the matching pool. Patients are generally matched at similar ages that may not be identical. The current example presents the case where two patients matched at the same index age.