. 2021 Apr 2;106(8):e2953–e2967. doi: 10.1210/clinem/dgab216

Table 1.

Definition of observed organ abnormalities reported in patient cohorts

Cohort	Liver Abnormalities	Kidney Abnormalities	Heart Abnormalities
Metreleptin-treated	NAFLD^a	Nephropathy^c	Coronary artery disease
	Hepatomegaly	Renal failure	Cardiac arrhythmia^h
	Cirrhosis	Renal disease	Cardiomyopathyⁱ
	Other^b	Other^d	Other^j
Metreleptin-naïve	NAFLD^a	Nephropathy^e	Coronary artery disease^k
	Hepatomegaly	Chronic renal failure^f	Cardiac arrhythmia^l
	Cirrhosis	ESRD	Cardiomyopathy^m
		Transplant	Heart failure
		Other^g	Transplant
			Otherⁿ

Abbreviations: ESRD, end-stage renal disease; NAFLD, nonalcoholic fatty liver disease.

^a Includes hepatic steatosis, nonalcoholic steatohepatitis, and steatohepatitis.

^b Includes fibrosis and hepatitis.

^c Includes proteinuria.

^d Includes glomerulosclerosis.

^e Includes albuminuria, microalbuminuria, and proteinuria.

^f Includes chronic renal failure, chronic renal insufficiency, and chronic kidney disease (all recorded in open-text fields).

^g Includes hematuria, kidney stones, nephromegaly, and renal hypoplasia.

^h Includes atrial fibrillation, tachycardia, and irregular heart beat.

ⁱ Includes any type of hypertrophy.

^j Includes any type of dilation, regurgitation, and other significant diagnoses in the heart entered by clinicians not already captured under other categories.

^k Includes atherosclerosis, bypass surgery, ischemia, myocardial infarction, and probable anteroseptal infarct (recorded in open text fields).

^l Includes atrial fibrillation, atrial flutter, bradycardia, and tachycardia (all but atrial fibrillation recorded in open-text fields).

^m Includes ventricular hypertrophy.

ⁿ Includes aortic insufficiency, aortic outflow murmur, aortic regurgitation, aortic stenosis, ascending aorta dilated, asymmetric septal hypertrophy with a sigmoid septum, atrial-level shunt and ventricular dilation, arteriovenous (AV) malformation, AV shunt, cardiomegaly, dilated left atrium, effusion pericardial, grade II/VI midsystolic murmur at the base of the left sternal border, heart murmurs, left ventricular relaxation deficit, mild mitral insufficiency, mild mitral valve regurgitation, mild tricuspid insufficiency, mild tricuspid valve regurgitation, mitral insufficiency, mitral valve insufficiency, mitral valve prolapse, mitral valve regurgitation, moderate mitral insufficiency, pulmonary AV malformation, pulmonic valve regurgitation, subaortic stenosis, subaortic ventricular septal defect, tricuspid insufficiency, tricuspid valve regurgitation, valvular heart disease, and ventricle diastolic-systolic dysfunction.