Table 5.
Causes of mortality by patient
| Patient Number | Type of Lipodystrophy | Gender | Country | Age at Death | Cause(s) of Mortalitya |
|---|---|---|---|---|---|
| Metreleptin-treated | |||||
| MT 1 | CGL | Female | US | 29 | ESRD |
| MT 2 | CGL | Female | US | 45 | ESRD |
| MT 3 | AGL | Female | US | 15 | Hepatorenal failure |
| MT 4 | AGL | Male | US | 50 | Heart failure; kidney failure |
| MT 5 | AGL | Male | US | 69 | Lymphoma |
| MT 6 | CGL | Female | US | 19 | Heart failure |
| MT 7 | CGL | Female | US | 25 | ESLD |
| MT 8 | CGL | Female | US | 18 | ESLD |
| MT 9 | AGL | Female | US | 20 | ESLD |
| MT 10 | CGL | Female | US | 20 | ESLD |
| MT 11 | CGL | Female | US | 23 | Heart failure |
| MT 12 | FPLD | Female | US | 31 | Respiratory failure |
| Metreleptin-naïve | |||||
| MN 1 | CGL | Male | US | 32 | Atypical interstitial pneumonitis; respiratory failure |
| MN 2 | CGL | Male | Turkey | 44 | Died after coronary artery bypass grafting operation |
| MN 3 | CGL | Female | Turkey | 62 | Myocardial infarction |
| MN 4 | CGL | Female | Turkey | 26 | Diabetic foot infection |
| MN 5 | CGL | Female | US | 30 | Cardiac arrest due to underlying nonischemic cardiomyopathy |
| MN 6 | CGL | Female | Brazil | 16 | Sepsis |
| MN 7 | CGL | Female | US | 18 | Heart failure related to valvular stenosis |
| MN 8 | CGL | Female | Brazil | 15 | Septic shock |
| MN 9 | CGL | Female | Turkey | 60 | Stroke |
| MN 10 | FPLD | Male | Turkey | 35 | Not documented |
| MN 11 | FPLD | Female | US | 39 | Not documented |
| MN 12 | FPLD | Female | US | 69 | Probable kidney failure |
Abbreviations: AGL, acquired generalized lipodystrophy; CGL, congenital generalized lipodystrophy; ESLD, end-stage liver disease; ESRD, end-stage renal disease; FPLD, familial partial lipodystrophy.
a As reported in patient medical records and by study investigators.