Table 2.
Baseline (2002–2004) metabolic characteristics of men and women with apolipoprotein measurements in the RISC study
| Men (N = 389) | Women (N = 475) | |||
|---|---|---|---|---|
| Median | 25th, 75th percentile | Median | 25th, 75th percentile | |
| Fasting glucose, mmol/l | 5.2 | (4.9, 5.5) | 5 | (4.7, 5.3) |
| Fasting insulin, pmol/l | 31 | (22, 45) | 30 | (20, 40) |
| IS-clamp (baseline), µmol/min·kg_FFM·nM | 118 | (86, 155) | 151 | (113, 194) |
| IS-OGTT (baseline), ml/min·m2 | 427 | (392, 460) | 447 | (411, 487) |
| IS-OGTT (year 3), ml/min·m2 | 414 | (379, 451) | 436 | (391, 481) |
| delta_IS-OGTT, ml/min·m2 | -13 | (-42, 18) | -8.3 | (-45.6, 22.7) |
| GISR (baseline), pmol / [min·m2·mmol/l] | 60 | (42, 88) | 55 | (36, 77) |
| Adiponectin, mg/l | 6.3 | (4.8, 7.9) | 9.2 | (7.2, 12) |
| Leptin, ng/ml | 4.4 | (2.2, 7.5) | 15 | (10, 25) |
| Cholesterol, mmol/l | 4.9 | (4.4, 5.5) | 4.8 | (4.23, 5.3) |
| HDL-cholesterol, mmol/l | 1.2 | (1.1, 1.4) | 1.5 | (1.3, 1.8) |
| LDL-cholesterol, mmol/l | 3.0 | (2.6, 3.6) | 2.8 | (2.3, 3.3) |
| Triglyceride, mmol/l | 1.1 | (0.8, 1.5) | 0.8 | (0.6, 1.1) |
| Free fatty acid, mmol/l | 0.43 | (0.35, 0.56) | 0.56 | (0.45, 0.70) |
| ApoA-I in HDL lacking apoC-III, mg/dl | 91 | (79, 103) | 103 | (89, 119) |
| ApoA-I in HDL containing apoC-III, mg/dl | 7.4 | (6.1, 8.9) | 8.4 | (7.1, 10.4) |
| % of apoA-I in HDL containing apoC-III, % | 7.6 | (6.5, 8.9) | 7.7 | (6.6, 8.8) |
| ApoB in LDL and VLDL lacking apoC-III, mg/dl | 71 | (60, 87) | 67 | (55, 80) |
| ApoB in LDL and VLDL containing apoC-III, mg/dl | 4.4 | (3.4, 5.5) | 4.0 | (3.1, 5.1) |
| % of apoB in LDL and VLDL containing apoC-III, % | 5.7 | (4.6, 6.9) | 5.8 | (4.7, 7.0) |
| ApoC-III, mg/dl | 9.9 | (7.6, 13.1) | 9.8 | (7.7, 12.3) |
| ApoC-III in HDL, mg/dl | 5.9 | (4.6, 7.6) | 5.6 | (4.6, 7.0) |
| ApoC-III in LDL and VLDL, mg/dl | 4.2 | (2.8, 6.0) | 4.1 | (2.8, 5.6) |
| ApoC-III to ApoA-I molar ratio | 2.6 | (2.2, 3.1) | 2.2 | (1.9, 2.6) |
| ApoC-III to ApoB molar ratio | 62 | (43, 79) | 62 | (47, 84) |
Abbreviations: ApoC-III to ApoA-I molar ratio, the molar ratio of apoC-III to apoA-I in apoC-III-containing HDL; ApoC-III to ApoB molar ratio, the molar ratio of apoC-III to apoB in apoC-III-containing LDL and VLDL; FFM, fat-free mass; GISR, glucose-induced secretory response; HDL, high density lipoprotein; LDL, low density lipoprotein; OGTT, oral glucose tolerance test; VLDL, very low density lipoprotein.