Table 1.

TLR4 stimulating DAMPs described in this review, their size, functionality, and primary location

Name	Size	Functionality	Primary location
HMGB1	215 amino acids	Chromatin-binding	Nucleus
S100A4	121 amino acids	Calcium-binding	Nucleus/cytoplasm
HSPB5	44 amino acids	Protein chaperone	Nucleus
CIRP	192 amino acids	RNA-binding	Nucleus
Fn-EDA	500 kDa glycoprotein	Collagen-binding	Extracellular matrix
Tenascin-C	2,000 kDa glycoprotein	Cell–cell signaling	Extracellular matrix