Table 2.

Outcome Assessments: Rating Scales Used by Independent Clinical Assessors

Treatment Area	Rating Scale	Parameters/Descriptors
Periorbital lines	Merz Aesthetic Crow’s Feet at Rest Grading Scale24	0 No wrinkles
		1 Mild wrinkles
		2 Moderate wrinkles
		3 Severe wrinkles
		4 Very severe wrinkles
Perioral lines	Merz Aesthetic Lip Wrinkles at Rest Grading Scale25	0 No wrinkles
		1 Mild wrinkles
		2 Moderate wrinkles
		3 Severe wrinkles
		4 Very severe wrinkles
Accordion lines	Modified Fitzpatrick Wrinkle Scale (MFWS)26	0 No wrinkles (no visible wrinkle)
		0.5 Very shallow, yet visible wrinkle
		1 Fine wrinkle
		1.5 Visible wrinkle, clear indentation less than 1 mm wrinkle depth*
		2 Moderate wrinkle (clearly visible, 1–2 mm depth*)
		2.5 Prominent and visible wrinkle (more than 2 mm and up to 3 mm depth*)
		3 Deep wrinkle (deep and furrow, more than 3 mm depth*)

* Wrinkle depth is based on estimation, not physical measurement.