Table 1.

Clinicopathological criteria or medication definitions.

Type and clinicopathological criterion or medication		Description
Binary
	BCGa instillation	First instillation of BCG documented 0-90 days after TURb
	Epirubicin	Epirubicin use documented 0-90 days after TUR
	Tuberculostatic agents	Use of isoniazid isonicotinylhydrazide, rifampicin, rifambutin, fluoroquinolones (ofloxacin, ciprofloxacin, levofloxacin, and moxifloxacin), ethambutol, clarithromycin, aminoglycosides (gentamicin, amikacin, tobramycin, kanamycin, and neomycin), or doxycycline documented –30 to 90 days of induction BCG (index to median day of BCG administration if no BCG)
	Spasmolytics or anticholinergics	Use of spasmolytics: oxybutynin documented –30 to 90 days of induction BCG (index to median day of BCG administration if no BCG)
	Antiphlogistics	Use of antiphlogistics: fluticasone documented –30 to 90 days of induction BCG (index to median day of BCG administration if no BCG)
	Topical steroids	Use of local topical steroids: betamethasone, clobetasol, diflorasone, fluocinoide, halobetasol, amcinonide, desoximetasone, propionate, triamcinolone, fluocinolone, hydrocortisone, desonide, alclometasone, and mometasone documented –30 to 90 days of induction BCG (index to median day of BCG administration if no BCG)
	Nonsteroidal anti-inflammatory drugs	Use of nonsteroidal anti-inflammatory drugs: aspirin, ibuprofen, naproxen, nabumetone, celecoxib, diclofenac, etodolac, indomethacin, ketoprofen, ketorolac, and piroxicam documented –30 to 90 days of induction BCG (index to median day of BCG administration if no BCG)
Numeric
	General description	Most recent (laboratory test) occurring 1-180 days after induction BCG computed 14 days before the next event (ie, TUR but not Re-TURc, recurrence, progression, or death) Difference between the most recent (laboratory test) occurring 1-180 days after induction BCG computed 14 days before next event and the most recent (laboratory test) occurring 90-0 days before induction BCG (index to median day of BCG administration if no BCG)
	Lymphocyte count (normal: 20%-40% differential)	N/Ad
	Neutrophil count (normal: 55%-70% differential)	N/A
	Monocyte count (normal: 2%-8% differential)	N/A
	Platelet count (K/μL)	N/A
	White blood cell count (K/μL)	N/A
	Creatinine level (mg/dL)	N/A
	Hemoglobin A1c (mmol/mol)	N/A
Computed percentage
	General description	Most recent (laboratory test) occurring 1-180 days after induction BCG computed 14 days before the next event (ie, TUR but not Re-TUR, recurrence, progression, or death) Difference between the most recent (laboratory test) occurring 1-180 days after induction BCG computed 14 days before next event and the most recent (laboratory test) occurring 90-0 days before induction BCG (index to median day of BCG administration if no BCG)
	Derived neutrophil-to-lymphocyte ratio	N/A
	Platelet-to-lymphocyte ratio	N/A

^aBCG: bacillus Calmette-Guérin.

^bTUR: transurethral resection of a bladder tumor.

^cRe-TUR: second-look transurethral resection of a bladder tumor.

^dN/A: not applicable.