Figure 2.

GBM proximity to the lateral ventricles impacts long-term outcome in rodents. (A) Quantification of BLI total flux fold change over time in the LV-proximal and LV-distal GBM tumor conditions (n = 7). (B) Representative BLI images in radiance (photons/second/centimeter/steradian) of immunosuppressed athymic nude mice bearing orthotopic patient-derived GBM at LV-proximal (left) and LV-distal (right) locations at five weeks post injection. (C) Kaplan-Meier survival curve of mice bearing tumors in LV-proximal and LV-distal sites (n = 3). The median survival for LV-proximal or LV-distal tumor bearing mice were 36 and 52 days, respectively. The data are presented as mean ± SEM. *p < 0.05, ****p < 0.0001.