Figure 3.

GBM proximity to the LV negatively influences Ki67 expression in the SVZ. (A–F) Representative images of immunohistochemical staining for Ki67 in GFP- cells of the SVZ (A–C) ipsilateral and (D–F) contralateral to the tumor. Red = Ki67, green = GFP, Blue = DAPI. This was compared between (A, D) LV-proximal, (B, E) LV-intermediate, and (C, F) LV-distal GBM groups. Scale bar = 50 μm. (G) Quantification of Ki67+ cell density in the SVZ comparing between the SVZ ipsilateral and contralateral to the GBM in LV-proximal (n = 6), LV-intermediate (n = 5), and LV-distal (n = 5) mice. Data are presented as mean ± SEM. **p < 0.01,