Table 1.

Cardiolipin Abnormalities in Patients with Neurological Disorders^a

Condition	Model/biological sample	Cardiolipin abnormalities	Refs
BTHS	Skeletal muscle, heart and platelets from BTHS patients	• 80% (skeletal muscle and platelets) and 20% (heart tissue) reduction of total CL	[23]
FTD	Serum from 40 FTD patients	• ∼ 20% decrease of total CL	[22]
TBI	Brain tissue from the pericontusional area of 10 TBI patients	• Increased CLox (1 h after TBI) • Increased MLCL by hydrolysis (4 and 24 h after TBI) • Increased TAZ expression (4 and 24 h after TBI)	[21]

^aAbbreviations: BTHS, Barth syndrome; CL, cardiolipin; CLox, oxidized CL; FTD, frontotemporal dementia; MLCL, monolysocardiolipin; TBI, traumatic brain injury; TAZ, tafazzin.