Table 2.
Literature review for risk of metabolic syndrome in LGA at birth
| Study (year) | Study population | Age affected | Research method | Result |
|---|---|---|---|---|
| Boney et al. (2005)45 | 179 | Childhood, adolescence | Cohort study | Children who were LGA at birth had a 2-fold increased risk of metabolic syndrome by 11 years of age (hazard ratio, 2.19; 95% CI, 1.25–3.82). Children who were LGA at birth and exposed to an intrauterine environment of either diabetes or maternal obesity were at increased risk of developing metabolic syndrome. |
| Wang et al. (2007)36 | 372 | Childhood | Cross-sectional study | LGA status increased the risk of metabolic syndrome, with hazard ratio of 2.53 (95% CI, 1.42–4.51) in obese children. |
| Kelishadi et al. (2008)46 | 4,811 | Childhood, adolescence | Cross-sectional study | Birth weight > 4,000 g in boys and < 2,500 g in girls increased the risk of metabolic syndrome (OR, 1.4; 95% CI, 1.01–2.05 and OR, 1.2; 95% CI, 1.1–1.4, respectively). |
| Guerrero-Romero et al. (2010)47 | 1,262 | Childhood, adolescence | Cross-sectional study | High birth weight (OR, 1.4; 95% CI, 1.2–10.9) was significantly associated with metabolic syndrome in children and adolescents. |
| Eyzaguirre et al. (2012)48 | 1,002 | Childhood, adolescence | Cross-sectional study | LGA infants were at higher risk of metabolic syndrome than were AGA infants among overweight and obese children and adolescents, by 8.3% and 5.6%, respectively. |
| Harville et al. (2012)49 | 2,078 | Childhood, young adulthood | Cross-sectional study | High birth weight for gestational age was associated with reduced risk of metabolic syndrome in those with low BMI but not in those with high BMI. |
| González-Jiménez et al. (2015)50 | 976 | Childhood, adolescence | Cross-sectional study | Infants born with a higher than average birth weight had a greater risk of developing metabolic syndrome in childhood and adolescence. |
| Romero-Velarde et al. (2016)51 | 120 | Childhood, adolescence | Cross-sectional study | Presence of metabolic syndrome was associated with a history of large birth weight (OR, 2.21; range, 1.01–4.82) in children and adolescents with obesity. |
LGA, large for gestational age; CI, confidence interval; OR, odds ratio; AGA, appropriate for gestation age; BMI, body mass index.