Table 1.

[11C]PBR28 SA-IRF ROI estimates and comparison with compartmental modelling and spectral analysis VT estimates

ROI	IRF estimates (min−1)			Correlation with VT estimates (Pearson’s r)
	HABs (Mean ± SD)	MABs (Mean ± SD)	HABs-MABs Rel Diff (Mean ± SD)	SA	2TCM1K	2TCM
Whole brain	0.144 ± 0.030	0.106 ± 0.011	37 % ± 8 %	0.91	0.92	0.93
Occipital lobe	0.156 ± 0.035	0.116 ± 0.009	34 % ± 8 %	0.86	0.91	0.92
Temporal lobe	0.141 ± 0.029	0.103 ± 0.009	37 % ± 8 %	0.90	0.93	0.92
Frontal lobe	0.150 ± 0.031	0.108 ± 0.013	38 % ± 9 %	0.89	0.89	0.91
Parietal lobe	0.151 ± 0.033	0.110 ± 0.011	37 % ± 9 %	0.89	0.90	0.93
Insular cortex	0.163 ± 0.034	0.122 ± 0.015	34 % ± 8 %	0.76	0.87	0.83
Cingulate cortex	0.158 ± 0.030	0.112 ± 0.011	41 % ± 9 %	0.88	0.89	0.92
Thalamus	0.154 ± 0.030	0.110 ± 0.014	39 % ± 9 %	0.81	0.89	0.92
Hippocampus	0.142 ± 0.030	0.104 ± 0.008	37 % ± 8 %	0.68*	0.92	0.93
Striatum	0.154 ± 0.031	0.116 ± 0.015	34 % ± 8 %	0.92	0.95	0.81
Cerebellum	0.169 ± 0.037	0.123 ± 0.016	37 % ± 9 %	0.89	0.92	0.95

*Not statistically significant

HABS high-affinity binders, MABS medium-affinity binders