Table 2.

[11C]PBR28 SA-IRF voxel-wise estimates and comparison with compartmental modelling and spectral analysis VT estimates

ROI	IRF estimates# (min−1)			Correlation with VT estimates
	HABS (Mean ± SD)	MABS (Mean ± SD)	HABs-MABs Rel Diff (Mean ± SD)	SA	2TCM-1K	2TCM
Whole brain	0.144 ± 0.030	0.104 ± 0.017	38 % ± 10 %	0.92	0.92	0.86
Occipital lobe	0.156 ± 0.037	0.111 ± 0.021	40 % ± 12 %	0.88	0.82	0.70
Temporal lobe	0.139 ± 0.030	0.100 ± 0.016	39 % ± 11 %	0.90	0.88	0.70
Frontal lobe	0.146 ± 0.031	0.107 ± 0.019	36 % ± 10 %	0.91	0.82	0.68
Parietal lobe	0.150 ± 0.034	0.110 ± 0.013	36 % ± 9 %	0.90	0.86	0.86
Insular cortex	0.166 ± 0.034	0.121 ± 0.017	37 % ± 9 %	0.74	0.83	0.84
Cingulate cortex	0.158 ± 0.030	0.112 ± 0.016	41 % ± 10 %	0.89	0.90	0.85
Thalamus	0.160 ± 0.029	0.112 ± 0.012	43 % ± 9 %	0.76	0.87	0.91
Hippocampus	0.144 ± 0.030	0.104 ± 0.012	38 % ± 9 %	0.77	0.96	0.92
Striatum	0.158 ± 0.032	0.115 ± 0.019	38 % ± 10 %	0.89	0.84	0.78
Cerebellum	0.172 ± 0.035	0.120 ± 0.028	43 % ± 13 %	0.92	0.91	0.87

^#SA-IRF voxel-wise estimates are defined as the average of all the SA-IRF voxel estimates within each region

HABS high-affinity binders, MABS medium-affinity binders