Table 1.
Characteristics of the study sample
| Meta-GWAS conducted in eMERGE3 and Geisinger (discovery)* | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Low back pain prompting health care utilization (LBP-HC) | Lumbosacral radicular syndrome (LSRS) | Lumbar spinal stenosis (LSS) | Lumbosacral radicular syndrome or lumbar spinal stenosis (LSRS/LSS) | ||||||
| Cases n=49,182 | Controls n=51,629 | Cases n=20,838 | Controls n=84,642 | Cases n=8,326 | Controls n=97,106 | Cases n=23,411 | Controls n=82,405 | ||
| Age | eMERGE3 | 63.4 (14.7) | 56.2 (16.7) | 64.5 (13.8) | 58.2 (16.5) | 69.3 (11.3) | 59.1 (16.3) | 65.3 (13.6) | 57.8 (16.5) |
| Geisinger | 63.1 (15.7) | 58.1 (17.7) | 64.6 (14.7) | 59.1 (17.4) | 72.5 (11.7) | 59.4 (16.9) | 65.3 (14.7) | 58.8 (17.3) | |
| Female Sex | eMERGE3 | 13,553 (57.1%) | 14,192 (51.2%) | 5,214 (56.7%) | 23,699 (53.3%) | 2,231 (49.8%) | 24,065 (52.4%) | 5,960 (55.1%) | 23,058 (53.5%) |
| Geisinger | 15,847 (62.3%) | 13,515 (56.5%) | 7,086 (60.9%) | 23,744 (59.1%) | 2,114 (55.0%) | 30,773 (60.1%) | 7,583 (60.2%) | 23,266 (59.2%) | |
| BMI (eMERGE) | eMERGE3 | 29.3 (6.3) | 28.6 (6.7) | 29.6 (6.1) | 28.8 (6.6) | 30.0 (5.9) | 28.9 (6.5) | 29.6 (6.1) | 28.8 (6.6) |
| Geisinger | 31.9 (7.6) | 30.8 (7.7) | 32.1 (7.4) | 31.0 (7.7) | 31.9 (6.7) | 31.2 (7.7) | 32.1 (7.4) | 31.0 (7.7) | |
*
n (%) or mean ± (SD) are presented; all participants were of European ancestry