Table 1.

Description of the proteins differentially expressed in the different types of liver disease.

A. AH (4 patients) in comparison to NAFLD (13 patients)
#	Uniprot Accession	Gene name	Peptide count [Unique]	log2(AH/NAFLD)	p-value	Description
1	P02656	APOC3	3[3]	−1.90	< 0.0001	Apolipoprotein C-III
2	P00738	HP	15 [7]	−1.40	0.0002	Haptoglobin
3	P02654	APOC1	3 [3]	−1.16	0.0005	Apolipoprotein C-I
4	P01764	IGHV3–23	2 [1]	1.39	0.0006	Immunoglobulin heavy variable 3–23
5	P02745	C1QA	4 [4]	2.13	< 0.0001	Complement C1q subcomponent subunit A
6	P01023	A2M	37 [34]	2.52	0.0008	Alpha-2-macroglobulin
7	P02746	C1QB	6 [6]	2.12	< 0.0001	Complement C1q subcomponent subunit B
8	P01859	IGHG2	9 [4]	1.17	0.0005	Immunoglobulin heavy constant gamma 2
9	P01861	IGHG4	8 [2]	1.18	0.0002	Immunoglobulin heavy constant gamma 4
10	P01860	IGHG3	13 [6]	1.58	< 0.0001	Immunoglobulin heavy constant gamma 3
11	P01857	IGHG1	13 [6]	1.48	< 0.0001	Immunoglobulin heavy constant gamma 1
B. NASH (8 patients) in comparison to SS (5 patients)
#	Uniprot Accession	Gene name	Peptide count [Unique]	log2(SS/NASH)	p-value	Description
1	Q6NXT2	H3F3C	4 [4]	2.11	0.0001	Histone H3 3C
2	P16104	H2AFX	6 [6]	1.91	< 0.0001	Histone H2AX
3	Q96A08	HIST1H2BA	4 [4]	1.60	0.0010	Histone H2B type 1-A
4	P01040	CSTA	3 [3]	−1.00	0.0006	Cystatin-A
5	P01717	IGLV3–25	4 [1]	−1.02	0.0015	Immunoglobulin lambda variable 3–25

Significance: The current investigation revealed the difference among various types of liver disease using LC-MS/MS of exosomes enriched from human serum samples of 24 patients where the most significantly up-regulation proteins were alpha-2-macroglobulin for alcoholic hepatitis and apolipoprotein C3 for nonalcoholic fatty liver disease.