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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Crit Rev Oncol Hematol. 2021 May 26;163:103368. doi: 10.1016/j.critrevonc.2021.103368

Figure 2. Hematopoietic stem cell retained steady state within the bone marrow niche is linked to a mobile behavior.

Figure 2

Mobilization of the hematopoietic stem cells from the bone marrow niche by drugs, that block CXCR4 (plerixafor, AMD3100) and integrin signaling [N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl) tyrosine, (BOP)] (AMD3100 + BOP, RX), inhibits hematopoietic stem cell mobility as well as its form fluctuations within the niche [43].